Formulation and Evaluation of Chitosan-Based Ampicillin Trihydrate Nanoparticles

Formulation and Evaluation of Chitosan-Based Ampicillin Trihydrate Nanoparticles

Purpose: To develop ampicillin trihydrate-loaded chitosan nanoparticles by modified ionic gelation method and evaluate their antimicrobial activity. Methods: Ampicillin trihydrate-loaded chitosan nanoparticles were prepared by ionic gelation method with the aid of sonication. Parameters such as the zeta potential, polydispersity, particle size, entrapment efficiency and in vitro drug release of...

Bioavailability of ampicillin (anhydrous) and ampicillin trihydrate.

Formulation and evaluation of intragastric buoyant tablets of amoxicillin trihydrate

Intragastric buoyant tablets, i.e., gastro retentive drug delivery systems of Amoxycillin trihydrate were prepared with the objective to obtain site-specific drug delivery for the stomach and to extend its duration of action. The sustained release of amoxicillin is desired because of its short biological half-life. Part icularly to treat Helicobacter pylori infections, the sustained release is ...

Formulation and characterization of anti-alzheimer’s drug loaded chitosan nanoparticles and its In vitro biological evaluation

Objective: The main objective of the study is to formulate hydrophilic drug loaded sustained release nanoparticles with the size of 200 nm and to increase the encapsulation efficiency of the drug. Methodology: The nanoparticles were prepared by simple ionic gelation method using various concentrations of chitosan and TPP. The prepared nanoparticles were evaluated for particle size, shape, charg...

Formulation and evaluation of Moxifloxacin hydrochloride ocular nanoparticles

The objective of the present study was to prepare controlled release formulation of Moxifloxacin hydrochloride ocular nanoparticles. The nanoparticles were prepared by solvent displacement method using Eudragit RL 100 as a polymer. Different formulations were prepared by varying the ratios of drug and polymer and varying the ratios of organic and aqueous phase. The formulations were evaluated i...